Graduate School of Health Sciences Kumamoto University

Research Subjects	Functional disease glycomics for establishing novel strategies of treatments Decoding intrinsic glycan information to elucidate the workings of biological nature
Research Focus	Mammalian cells produce sugar chain molecules which are essential for the fine tuning of cellular functions in response to altering cellular microenvironments. However, the biological information described in sugar chains has not been decoded at all yet. Impairment of cellular functions causes a production of aberrant sugar chains, which can be detected as a sign of the onset of diseases. Recently, we have elucidated that the dysregulation of cellular glycosylation alters and impairs cellular functions that evokes various diseases encompassing type 2 diabetes and tumor metastasis. Currently, we address the fundamental scientific question how sugar chains regulate cellular functions and are involved in pathogenesis of diseases. Moreover, we are embarking on the drug discovery based on the pharmacological engineering of the cellular glycosylation system.
Maximum number of acceptable foreign students	1

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